How Antioxidants Protect Your Skin
Skin oxidative damage results from an imbalance between free radical generation and antioxidant defenses, of which unfavorable consequences include aging, increased risk of skin diseases, expedited loss of collagen and elastin, increased DNA damage, high skin sensitivity, and increased skin pigmentation.
Epigenetically regulated expression of the anti-oxidative stress genes generates gene products-antioxidant protein/enzymes, which can scavenge reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), the superoxide anion radical (O2-) and the hydroxyl radical (.OH). The ROS generally arises from chemical, physical, and metabolic challenges. The antioxidants usually include antioxidant enzymes such as SOD, catalase and glutathione peroxidase and non-enzymatic antioxidants such as vitamin E, C, A, flavonoids and carotenoid. Antioxidant plays the most important and essential basis in delaying skin aging through decreasing skin oxidant damage, stimulating collagen production and reducing loss of collagen and elastin.
Layer 1. skin epidermis: as initial barrier to oxidant assault, it provides endogenous antioxidant action. Layer 2. skin microbes: There are approximate one million bacteria per cm2 in human skin. As an integral part of the skin barrier, skin microbes can affect skin health by modulating host immune responses and the skin barrier function. Common bacteria on skin can secret antioxidant substance including RoxP to protect host skin from oxidative stress.
Your skin is dynamic which is generated by interaction with environment and controlled by epigenetics at gene and protein level. However, the skin antioxidant level will be decided eventually by the activity of enzyme and non-enzyme molecules on your skin . Thus, only a direct skin sample antioxidant test can truly identify the antioxidant ability of your skin and determine which skincare products are best to suit you.
Antioxidant skincare products can also provide exogenous antioxidant action and can be considered as layer 3 of the skin antioxidant system when these products are applied to skin. >90% skincare products claim to have antioxidant function but in fact it is not true, even if these products contain antioxidant ingredients. Thus, only a direct product antioxidant test can truly identify the antioxidant ability of your skincare products and determine which skincare products are truly effective and suited for you.
Truly Data Backed Skin Antioxidation Self Test
Skin antioxidant self-test identify both your basic skin antioxidant status and skin antioxidant level after applying skincare product/regimen in different skin area.
Using routine product regimen then tested with skin antioxidant self-test. Non-invasive skin samples were collected and tested according to skin antioxidant self-test instruction. The color signal intensity was correspondently measured by using spectrophotometer. Condition 1: basic skin status, no skincare products applied overnight. Condition 2: 2 hours after using skincare products. Eye outer corner: using product 13+14+16+20; Face: using product 13+16+26+32; Hand: using product 40.
Skin antioxidant self-test helps to identify actual effect of the best selected regimens after applied to skin.
Using product regimens selected by skincare product antioxidant self-test and then tested with skin antioxidant self-test kit. Non-invasive skin samples from eye outer corner were collected and tested according to skin antioxidant self-test instruction. The color signal intensity was correspondently measured by using spectrophotometer. Regimen 1: product 7+14; Regimen 2: Product 7+14+15+20. Condition 1: basic skin status, no skincare products applied overnight; Condition 2: after wash in the morning; Condition 3: 4 hours after using the regimen 1 or 2; Condition 4: 8 hours after using the regimen 1 or 2.
Skin antioxidant self-test helps to identify and compare actual effect of the best selected regimens after applied to skin in a time length.
Using product regimens selected by skincare product antioxidant self-test and then tested with skin antioxidant self-test kit. Non-invasive skin samples from eye outer corner were collected and tested according to skin antioxidant self-test instruction. The color signal intensity was correspondently measured by using spectrophotometer. Regimen 1: product 7+14; Regimen 2: Product 7+14+15+20. Condition 1: Regimen 1 or 2 was applied overnight; Condition 2: after wash in the morning; Condition 3: 4 hours after using the regimen 1 or 2 again; Condition 4: 8 hours after using the regimen 1 or 2 again.
Skincare product antioxidant self-test helps to identify true antioxidant level of various skincare product.
Actual antioxidant effect of 30 popularly used products claimed to have antioxidant function. Different skincare products were tested with skincare product antioxidant self-test kit. The color signal intensity was correspondently measured by using spectrophotometer. Products 11-16 are regular serum; Product 17-22 are eye serum; Product 23-28 are lotion; Product 29-34 are cream; and Product 35-40 are sun protection cream.
Skincare product antioxidant self-test helps to identify actual antioxidant level of skincare products claimed to contain strong antioxidant ingredients and helps to choose the best and really effective one from these products.
Actual antioxidant effect of 10 skincare serum products containing >15% vitamin C and claimed to have strong antioxidant function. The products were tested with skincare product antioxidant self-test kit. The color signal intensity was correspondently measured by using spectrophotometer.
Skincare product antioxidant self-test helps to create the best rational regimen for your routine skincare by dynamically testing the new products or the stability of products/regimen currently being used.
Combination effect of several products claimed to contain multi-antioxidants. The products were tested with skincare product antioxidant self-test kit. The color signal intensity was correspondently measured by using spectrophotometer. Combination 1: Products 13+14+16+20; Combination 2: Products 7+14+15+20; Combination 3: Products 8+13+14+20; Combination 4: Products 7+15; Combination 5: Products 7+15+20; Combination 6: Products 7+14.
Questions? Answers.
Ordering the Test
Skintelli skin antioxidant rapid self-test is a direct-to-consumer at home self- test developed by New York-based biotechnology company EpigenCare Inc. The purpose of the test is to detect antioxidant status of your skin. The test is extremely simple and convenient, can be performed by yourself at home and can be completed within 10 min. The skin antioxidant level in natural states and applying skincare products is critical for skin health and preventing/reducing skin aging. This test can help you to clearly know your skin’s antioxidant levels and what the skincare products can be best suited for you.
You will gain three types of insights:
- An skin antioxidant score . This score represents your skin antioxidant level. This calculation is based on the reaction of oxidative stress with skin antioxidant protein/enzyme and small/organic molecules from skin cells and skin microbiome .
- A recommendation of the individualized skincare products/regimens if you submit your test data online of Skintelli. These products/regimens are validated to have the true antioxidant effects and the best-suited for you skin.
SKINTELLI does not offer medical, diagnostic, or health condition assessments and is strictly for cosmetic applications. For health concerns about your skin, seek the advice of a dermatologist or physician.
For skin self-test, you use an included non-toxic and safe adhesive disc. For skincare products, you use the included test picks which you dip into the products. You can see videos of the usage in action at https://skintelli.com.
As much as you like. Antioxidant capacity differ between skincare products and antioxidant levels directly on your skin also change upon application of skincare products, even up to a day or two after application and wash.
Results are immediate through the color-based scoring system included in the kit. Additional assessment can be conducted by inputting your results online along with a brief personalization questionnaire. At this time, the bonus assessment is free of charge. The assessment results are available within 72 business hours upon submission.
SKINTELLI is currently available in the USA and can be purchased directly on our website, as well as through online retailers including Amazon and Walmart.
Any unopen and unregistered SKINTELLI sample collection kits may be returned for a refund within 14 days, minus a $10 restocking fee. Once the kit has been open, we regrettably can no longer issue a refund. Please report any damaged or incomplete kits immediately upon receipt or within 14 days in order to qualify for a replacement.
The Science
For Skintelli Skin Quality Detection (anti-oxidant rapid self-test ) Kit
- Use touch-done sample collection technology to noninvasively collect antioxidant protein/enzyme and small/organic molecules from skin cells and skin microbiome.
- ). Use an innovative technology to measure total antioxidant activity of both enzymatic and non-enzymatic antioxidant species from nano-scale amount of a sample by detecting electron/atom transfer reaction of oxidative stress.
- Quick, portable and colorimetric reaction allows to self-test true and real-time world environment of antioxidant status in your skin at home.
For Skintelli of Skincare Product Quality Detection (anti-oxidant rapid self-test) Kit
1). Directly correct tiny amount of skincare product from the product containers to detect off-skin functions or use touch-done sample collection technology to noninvasively collect samples from skin after applying skincare products to check on-skin effect of the skincare products
2) Use an innovative technology to measure total antioxidant activity of both enzymatic and non-enzymatic antioxidant species from nano-scale amount of a sample by detecting electron/atom transfer reaction of oxidative stress.
3) Quick, portable and colorimetric reaction allows to self-test true and real-time antioxidant function of skincare products before and after applying to your skin.
Antioxidants are substances that may prevent or delay some types of cell damage caused by oxidative stress from the environment. It can occur naturally (such as being found in foods) as well as be added into skincare products.
Increased production of reaction oxidative species (ROS) from the environment leads to mtDNA damage, and consequently to a general decline in mitochondrial function that, in a vicious cycle-like effect, results in more oxidative stress. ROS initiates a signal transduction cascade that contributes to skin structure changes and photoaging. Oxidative stress resulting from excessive ROS production causes various kinds of cell damage via complex molecular signaling pathways. ROS may further damage the skin directly via other mechanisms, such as increasing the expression of MMP. DNA mutation, lipid peroxidation and protein oxidation caused by ROS result in the development of skin aging and photoaging such as brown spots and wrinkles.
Data Privacy
When registering the SKINTELLI self-test online, you can use any pseudonym to retain your anonymity if desired. However, we do require a working e-mail address so that you can access and view your test results. Moreover, we do ask a series of lifestyle and demographic questions so that we can correlate this information to your antioxidant score in order to provide you with an individualized assessment.
To maintain sample security and data accuracy, we use a range of technical, physical, and administrative procedures to protect the privacy information we collect including sample and testing data so that unauthorized access or disclosure will be prevented. All online data transactions are encrypted over SHA-256 standards. We are constantly exploring new and cutting-edge technologies to strengthen privacy and security measures.